KTx-CONNECT improves immunosuppression adherence with a clinician-designed digital program.
GraftWise Health is building KTx-CONNECT: a web-based adherence platform for kidney transplant recipients and care teams with smart reminders, behavioral nudges, patient-reported data, and actionable dashboards.
Solution
KTx-CONNECT is digital adherence infrastructure that supports recipients, families, and transplant teams without adding clinic burden.
Smart reminders
Web-based dosing schedules, refill prompts, and escalation logic when doses are missed.
Patient-reported data
Lightweight check-ins for barriers, side effects, and confidence, designed for teen and adult users.
Clinician dashboards
Surface risk signals early, prioritize outreach, and document interventions in a consistent workflow.
How it works
A clinic-embedded workflow that helps teams identify barriers early, personalize support, and track progress over time.
1) Capture barriers early
Recipients and caregivers complete brief, nonjudgmental barrier check-ins. The Barriers Assessment Tool (BAT) was designed for routine clinic use and quality improvement implementation.
- Patient-centered barrier inventory (BAT)
- Designed for reliable clinic workflow (PDSA/QI implementation)
- Actionable targets for support and coaching
2) Stratify risk and prioritize outreach
Identified adherence barriers are associated with higher subsequent rejection risk, supporting early identification and intervention.
- Turn barrier check-ins into a clear, prioritized outreach plan for the care team
- Team dashboard to track barriers, signals, and follow-up
- Configurable thresholds to match your program
3) Deliver targeted, multicomponent support
KTx-CONNECT operationalizes evidence-based adherence promotion (education, planning, problem-solving, and habit supports) and tracks response over time.
- Tailored coaching-style nudges and micro-interventions
- Clinic pathways and documentation fields
- Progress summaries for recipients, families, and the team
4) Measure outcomes and program value
Published implementation work shows that structured adherence promotion can reduce rejection and can be cost-saving.
- Use structured adherence promotion workflows with measurable follow-through
- Track outcomes and value with exportable, stakeholder-ready reporting
- Exportable reports for QI, research, and stakeholder reporting
Proof, Not Promises
The research and measurement model guiding our approach.
Measure barriers in a clinic-ready way
A brief, nonjudgmental barriers inventory supports routine use in transplant workflows and helps convert “nonadherence” into actionable targets.
Selected work: Varnell et al., Pediatric Transplantation (2017); Varnell et al., Children (2023)
Barriers predict risk
In pediatric and young adult kidney transplant recipients, identified adherence barriers were associated with higher subsequent rejection risk, supporting early detection and early intervention.
Selected work: Varnell et al., Pediatric Nephrology (2021)
Interventions can change outcomes and value
Structured adherence promotion has been associated with fewer late rejection events and modeled as cost-saving, reinforcing the case for scalable, team-based adherence programs.
Selected work: Hooper et al., AJKD (2021); Varnell et al., AJKD (2022)
What we operationalize
- Early capture: brief barrier check-ins designed for routine clinic use
- Tracking: longitudinal barrier trends, engagement, and adherence signals
- Action: clinic pathways tied to the barriers that matter for each patient
- Learning loop: exportable metrics for QI and research
Selected publications
- Varnell et al. Barriers to adherence in pediatric kidney transplantation. Pediatric Transplantation (2017).
- Varnell et al. Adherence barriers and subsequent acute rejection risk. Pediatric Nephrology (2021).
- Hooper, Varnell et al. Medication Adherence Promotion System (MAPS) in kidney transplantation. AJKD (2021).
- Varnell et al. Cost-effectiveness of MAPS-based adherence promotion. AJKD (2022).
- Varnell et al. Barriers Assessment Tool (BAT): clinical utility and follow-up outcomes. Children (2023).
- Dawson, Amatya, Norwood (eds.). Psychosocial considerations in pediatric kidney conditions. (2024).
Full citations and PDFs available upon request.
Security and privacy
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Data protections
- Encryption in transit and at rest (configure based on hosting)
- Role-based access controls for care teams
- Audit logs for key user actions
- Configurable retention policies
Implementation
- Pilot planning and success metrics definition
- Clinic onboarding and training materials
- Content customization for local workflows
- Ongoing support and iteration
Contact
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What to include
- Population (adult vs pediatric, years post-transplant)
- Preferred adherence signals (self-report, refill, etc.)
- Care-team workflow (who triages alerts)
- Target outcomes (missed doses, tac variability, PROs)
Contact
Email: hello@graftwisehealth.com